PAL-GHK (Topical)

Buy PAL-GHK Topical Peptide Europe

This product is intended for research purposes only. To be used by trained professionals only.

PAL-GHK is a synthetic peptide built by the addition of palmitoyl to the GHK sequence, forming a molecule that closely resembles a chain of type I collagen fragments. This unique structure increases its ability to pass through the stratum corneum, reaching deeper layers of skin tissue in test models. [1]

In laboratory setups, PAL-GHK interacts with fibroblasts, stimulating collagen synthesis and supporting the skin’s extracellular matrix (ECM). This is where the skin gets its structure and elasticity. Researchers often note improved skin thickness and flexibility in controlled environments. [2]

Its compatibility with liposomes and high aqueous solubility makes it ideal for experimental formulation designs. When tested with lipid-based carriers, it shows promising results in topical penetration and targeted delivery in lab studies.

Known within research as more than just a laboratory bench curiosity, this peptide is used in early-stage regenerative skin science and wound healing simulations.

For research use only. Not for human or cosmetic application.

Potential Benefits of PAL-GHK Topical Peptide

PAL-GHK has shown potential in laboratory experiments by encouraging collagen production while slowing collagen breakdown. Its interaction with fibroblasts leads to increased elastin and protein expression, improving structure and minimizing the look of wrinkles in preclinical skin models. [3]

PAL-GHK topical peptide also helps strengthen the lipid matrix, offering protection against oxidative stress caused by reactive oxygen species, reactive nitrogen species, and reactive carbonyl species. These harmful active radicals can damage skin proteins and break down ECM components. [4]

Some studies have noted that PAL-GHK may help form ghk peptide nanofibers, which act alongside hyaluronic acid to enhance skin hydration and elasticity. These structures are vital in experimental skin treatments that deal with dehydration or loss of firmness.

In injury models, PAL-GHK has been observed supporting cellular behavior at the site of a wound, potentially mimicking natural wound healing processes. This includes reduced inflammation, increased fibroblast activity, and restoration of ECM proteins.

While combination lip treatments featuring PAL-GHK and hyaluronic acid are appearing in cosmetic prototypes, robust lab-based evidence specifically on lip-targeted effects is still limited. Some placebo-controlled cream studies exist, but findings are mostly from small-scale trials and not yet conclusive.

Nonetheless, these early signals make PAL-GHK a compelling tool in the development of functional skin care products under lab testing protocols.

How Should PAL-GHK Topical Peptide Be Stored?

PAL-GHK topical peptide should be stored in a cool environment between 2°C–8°C for short-term stability. For extended storage, freezing at –20°C is ideal. As a sensitive molecule, it should be protected from light, moisture, and oxygen to maintain purity.

Avoid repeated freeze-thaw cycles, which may degrade the formulation and reduce its biological activity. Using airtight containers helps preserve its effectiveness in ongoing research focused on penetration, ECM repair, and peptide-based delivery systems using lipids.

Proper storage ensures consistent performance in skin model testing and supports reproducible results across diverse peptide trials.

Direct Peptides is a leading supplier of peptides for vitro testing in laboratory experimentation. Shop the full range of Topical Peptides here.

References:

[1] Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987.

[2] The impact of palmitoyl glycyl-histidyl-lysine on phospholipid model membranes, Journal of the Taiwan Institute of Chemical Engineers Available online 14 December 2023 by Tzung-Han Chou et al.

[3] Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.

[4] Topical Peptide Treatments with Effective Anti-Aging Results, Cosmetics 2017, Volume 4, Issue 2, 16; by Silke Karin Schagen

Molecular formula: C30H54N6O5

Molecular weight: 578.8 g/mol

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Europe Direct Peptides website: https://europe.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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