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AMKP, or Adenosine Monophosphate-activated Protein Kinase, is a peptide involved in cellular energy homeostasis. It serves as a metabolic switch that regulates several intracellular systems including the cellular uptake of glucose, the beta-oxidation of fatty acids, and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.
The activation of AMPK has several benefits including enhancing insulin sensitivity which can be beneficial in managing type 2 diabetes mellitus. It also promotes weight loss and reduces fat storage by inhibiting the activity of acetyl CoA carboxylase (ACC), an enzyme that plays a crucial role in fatty acid synthesis and oxidation. Moreover, AMPK activation also appears to have anti-inflammatory effects and has been shown to reduce the expression of inflammatory markers.
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Cardiovascular Health: Studies have shown that the activation of AMPK by GLP-1 analog liraglutide can inhibit endothelial cell inflammation, thus providing cardiovascular benefits to patients with Type 2 diabetes [1].
Hypertension Treatment: The modulation of the AMPK/SIRT1/PGC-1α/FOXO3 pathway by bioactive peptides and exercise has been found to provide potential therapeutic benefits for hypertensive rats [2].
Lipid Metabolism Regulation: Atrial natriuretic peptide (ANP) has been shown to regulate lipid mobilization and oxygen consumption in human adipocytes by activating AMPK [3].
Longevity and Caloric Restriction: Adenosine nucleotide biosynthesis and AMPK have been found to regulate adult lifespan and mediate the longevity benefit of caloric restriction [4].
Diabetic Vascular Dysfunction Treatment: The wheat germ-derived peptide ADWGGPLPH has been demonstrated to serve as an antioxidant that provides benefits in the treatment of diabetic vascular dysfunction by modulating the PKCζ/AMPK/NOX4 pathway [5].
[1] https://pubmed.ncbi.nlm.nih.gov/24835252/
[2] https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC9319799/
[3] https://pubmed.ncbi.nlm.nih.gov/21672517/
[4] https://pubmed.ncbi.nlm.nih.gov/23312286/
[5] https://www.researchgate.net/ publication/342454015
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